The vigorous cytokine response of immune cells to Gram-negative bacteria is primarily mediated by a recognition 5 molecule, Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharide (LPS) and initiates a series of intracellular NF-kappaB-associated signaling events.Recently, bladder epithelial cells (BECs) were reported to express TLR4 and t
This issue is dedicated to the memory of Cat-Supplies Paolo Cantiani, associate editor of this journal and senior researcher at the CREA Research Center for Forestry and Wood (Italy), recently passed away.Studying for passion rather than for work, he dedicated himself to research on silviculture and forest management planning.A free mind and determ
We 5 solve the Cauchy problem for inhomogeneous distributed-order equations in a Banach space with a linear bounded operator in the right-hand side, with respect to the distributed Caputo derivative.First we find the solution by using the unique solvability theorem for the Cauchy problem.Then the results obtained are applied to the analysis of a di
PURPOSE: Complete androgen blockade (CAB) does not prolong overall survival (OS) in patients with castration refractory prostate cancer (CRPC).Although there is variable clinical benefit with second-line hormone manipulation, we do not know which patients might benefit the most.OBJECTIVES: To identify clinical predictors of benefit of complete andr